In numerous studies, curcumin’s anti-inflammatory effects have been shown to be comparable to the potent drugs hydrocortisone and phenylbutazone as well as over-the-counter anti-inflammatory agents such as ibuprofen. Some clinical studies have further substantiated curcumin’s anti-inflammatory effects. While most anti-inflammatory drugs only impact one or maybe two of these mediators, curcumin exerts actions against all of them.